Name:……………………………… Academic Number:
Biochemistry Exam For Second year students
الفرقة الثانية (نظام حديث) PartII
1- Write full account on: - (10marks)
A-Outline diagram about the biosynthesis of high energy phosphate
bonds(ATP).Explain fully the different shuttle systems for
transferring electrons in nerve and liver cells. (5 Marks)
B- Lactic acid metabolism. (2.5 marks)
C--Types of bilirubin. (2.5 marks)
2- Mention of the following . (10marks)
A- Metabolic shuttles are important tools in Lipid metabolism in the body, discuss one of them. (2.5 marks)
B-Phosphorus play important role in regulation of lipid and
Cholesterol metabolism, discuss one of them. (2.5 marks)
A- What is the difference between: ( 5 Marks)
1- Pyruvic dehydrogenase and pyruvic decarboxylase.
2- Carotenes and Carnitine.
3-Isocitric dehydrogenase cytoplasmic and mitochondrial types.
4- Citrate layase & Citrate synthetase.
5- HMG CoA reductase and HMG CoA Layase
3- CHOOSE THE CORRECT ANSWER : ( 0.5 x10=5marks)
(1)Which one is the key enzyme in gluconeogenesis:
(A) Pyruvate kinase. (B)Enolase.
(C) Pyruvate carboxylase. (D) Glucokinase.
(2)The enzyme which is lacking in muscles but present in normal liver is:
(A)Glucokinase. (B) Glucose-6-phosphatase.
(C) Glycogen phosphorylase. (D)Creatine kinase.
(3) Pentose phosphate pathway produces:
(A) ATP. (B) NADPH+H.
(C) NADH+H. (D) FADH2.
(4) All of the following compounds are intermediates of the Krebs cycle
Except:
(A) Isocitrate (B)Malate.
(C) Pyruvate. (D)Oxaloacetate.
(5) Succinyl CoA may undergo one of the following reactions EXCEPT:
(A) Heme synthesis. (B) Activation of Ketone bodies.
(B) Gluconeogenesis (D) Glycosaminoglycans.
(6) Increased cholesterol level in blood is inhibited by :
(A) HMG CoA synthetase (B) HMG CoA reductase.
(C) Mevalonate kinase (D) HMG CoA Layase.
(7) Complete oxidation of one molecule of palmitic acid produces:
(A) 97 ATP. (B) 127 ATP.
(C) 129 ATP. (D) 132 ATP.
(8) Phosphodiesterase :
(A) Stimulated by catecholamines. .
(B) Their action leads to convertion of cAMP to AMP.
(C) Inhibited by insulin (D) All of the above.
(9) Ketone bodies utilization occurs in:
(A) Extra Hepatic cytoplasm. (B) Extra hepatic mitochondria.
(B) Hepatic cytoplasm. (D) Hepatic mitochondria.
(10) Initial step for De novo synthesis of fatty acid is due to formation of:
(A) HMG CoA. (B) Succinyl CoA.
(C) Malonyl CoA (D) Methyl malonyl CoA.
Good Luck
Prof.Dr.Kh. Kahilo