| Abstract | Aim: The aim is to study VEGF, HER2/neu, EGFR and c-kit expression by immunohistochemistry in HCC in Egyptian cirrhotic patients.
Patients & Methods: Fifty four cases of HCC were included in this study, 38 cases of them were hepatectomy samples. All were histologically diagnosed and graded. There were 10 cases well differentiated, 22 moderately differentiated, 16 poorly differentiated and 6 undifferentiated HCC.
Results: All patients had cirrhotic livers, and the most common etiology was HCV (59%). Immunohistochemical expression of VEGF, HER2/neu, c-kit and EGFR in HCC cases were studied with scoring of each case. Statistical analysis was done to correlate the results. There were 48/54 (88.9%) VEGF, 22/54 (40.7%) HER2/neu, EGFR 6/54 (11%) and 28/54 (70.4%) c-kit positive cases. There was statistical significant correlation between expression of VEGF and histopathological grading of HCC but, it was statistically insignificant with the others
Conclusion: VEGF is an important molecular target for anti angiogenic therapy in HCC patients. |