| Abstract | ASSOCIATION OF VITAMIN D RECEPTORS GENES POLYMORPHISM (APA 1, AND TAQ 1) WITH TYPE 1 DIABETES IN SAUDI ARABIA (KSA)
El-Sayed El-Badrawy, Zein S.Ibrahim, Amal Abedel Aziz, Mohamed M. Kamel, Gaber M Shehab, and Ayman Kamal
Department of Biochemistry , Department of Physiology, Department of internal medicine, Department of
Pharmacology and Forensic Medicine , Faculty of Medicine , Taif University, kingdom Saudi Arabia. Faculty of Specific Education, Mansoura University6, Department of Physiology, Faculty of Veterinary Medicine, Kafr El- Sheikh University , Department of Clinical Pathology, NCI, Cairo University, Department of, Clinical Pathology, Assuit University, Department of Biochemistry, Faculty of Agriculture, Cairo University,Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Suez Canal University10, Egypt
ABSTRACT
Type 1 diabetes mellitus (TIDM) results from an immune-mediated destruction of insulin-producing-cells in the pancreatic islets of Langerhans. There are clear differences in immunogenetic predisposition to type1 diabetes among countries. Studies have indicated that vitamin D supplementation in early childhood decreases the risk of TIDM. Vitamin D exerts its action via the nuclear vitamin D receptor (VDR), which shows an extensive polymorphism. VDR gene polymorphisms have been associated with altered gene expression or gene function. Four single nucleotide polymorphisms (SNPs) in the VDR gene produce variation in four recognition sites. These recognition sites variants include Fok I, Bsm I, Apa I and Taq I. This study was conducted to investigate the relationship between VDR gene polymorphisms and the incidence of TIDM in Saudi people living in Taif region. Apa I recognition site was found in low frequency in diabetic patient (7/37)18.9% while, its frequency was high (8/14) 57.1% among normal children. Taq I has two recognition sites. The first was found at nucleotide number 293 that was found in a frequency of (1/14) 7.1% in normal non-diabetic individuals while it was detected in (7/37) 18.9% in diabetic patients. The second Taq I recognition site was found at nucleotide number 494 without any differences between diabetic and normal individuals. This study indicates that there is an association between VDR genetic polymorphism and incidence of TIDM in Saudi people live in Taif region. [El-Sayed El-Badrawy, Zein S. Ibrahim, AmalAbedel Aziz, Mahmoud M Kamel, Gaber M Shehaband, Ayman
Kamal. Association of Vitamin D Receptors Genes Polymorphism (Apa I, and Taq I) with type 1 diabetes in Saudi Arabia (KSA). |