| Abstract | Considerable attention has recently been devoted to the formation of stable charge-transfer complexes that result from the reaction between acceptors and drugs. This interest stems from the significant physical and chemical properties of these complexes. In this paper, the charge-transfer complexes formed between the ephedrine (Eph) drug as a donor with picric acid (Pi) and quinol (QL) as a ?–acceptors have been synthesized in methanol as a solvent at room temperature and spectroscopically studied. Based on the elemental analyses (C, H and N) and photometric titrations, the interaction between both picric and quinol ?–acceptors with Eph donor formed via a stoichiometry (drug: acceptors) of 1:2 and 1:1, respectively. Benesi-Hildebrand and its modification methods were applied to estimate the spectroscopic and physical data. The spectroscopic techniques such as (infrared, 1H-NMR, and UV-vis) spectra, positron annihilation lifetime and thermo gravimetric analysis (TG) were used to characterize the chelating behavior of the synthetic CT complexes. The positron annihilation lifetime parameters were found to be dependent on the structure, electronic configuration and molecular weight of CT complexes. Finally, the antimicrobial activity of the CT complexes was determined against various bacterial and fungal strains. |