CHUNICHI SHINBUN 1/15/2009

Malaria is a virulent infectious disease affecting tropical region. The research group of professor Kitade at the center of advanced drug research, and for the first time in the world, succeeded to purify and examine the substrate specificity of an important metabolic enzyme for the life and biological activity of plasmodium parasites. Recently, the development of drug resistance is a hot issue and the search for new drugs is the only way to solve the problem.

The enzyme TMP kinase is recovered with exceptional substrate specificity. Kitade group used the gene encoding this enzyme, expressed in E. coli and examined its properties. The enzyme showed properties highly different from the human enzyme, so that, the inhibitors of this enzyme will be effective drugs without side effects on humans. In order to provide treatment for malaria epidemics, the Egyptian doctoral student Mahmoud Kandeel contributed to these experiments. A nice publication was provided in the January issue of Parasitology. Professor Kitade said that Malaria victims are increasing around the world and we are working hardly to provide a new drug for saving the lives of people all over the world.

الترجمة العربية

جريدة تشونيتشى شينبون 15 يناير

تعد الملاريا واحده من الامراض المعديه الحاده شديدة الضراوه التى تصيب الاماكن الاستوائيه. ولأول مره فى العالم نجحت مجموعة البحث للبروفسير/ كيتادا  فى مركز البحوث المتقدمة للادويه فى مدينة جيفو اليابان فى تنقية واختبار الماده الخاصه بانزيم ايضى هام لحياة و الوظائف الحيويه لطفيل البلازموديوم. وفي الآونة الأخيرة ،كان تطور خاصية مقاومة الادويه واحده من اهم  القضايا الساخنة  والبحث عن أدوية جديدة هو السبيل الوحيد لحل هذه المشكلة. ويتميز انزيم ال تى ام بى كيناز لطفيل البلازموديوم لاتحاده بمواد خاصه استثنائيه لا يستطيع انزيم الانسان الاتحاد معها. وقد استخدمت مجموعة البوفسير كيتادا الجين المعبر عن الانزيم داخل الايشيريشيا كولاي واختبرت خصائصه. وقد اظهر الانزيم خصائص مختلفه جدا عن تلك الخاصه بالانزيم البشرى ولذلك سوف تكون مثبطات هذا الانزيم عقارات فعاله بدون آثار جانبية على البشر.

من أجل تقديم العلاج لمكافحة اوبئة الملاريا قام طالب الدكتوراه المصرى محمود قنديل بهذه التجارب.وقد نشر هذا البحث الرائع فى اصدار يناير لجريدة الباراسيتولوجى البريطانيه. وافصح البروفسير كيتادا  عن تزايد ضحايا الملاريا حول العالم و نعمل  الان بجديه لانتاج عقار جديد لإنقاذ حياة الناس في جميع أنحاء العالم.

 الترجمة الانجليزية 

Extraction of new protein from malaria in a genome structural analysis joint research and possibility of development of new antimicrobials presented by the professor Kitade of Gifu University. The professor Yukio Kitade (53 years); dean of the school of drug discovery and medical information sciences, with a joint research project with the biomedical engineer doctoral student Mahmoud Kandeel (33 years) supported by the Egyptian government for development of new antimalarial drug. The researchers investigated the human and plasmodium TMP kinase and finally in the 16 th of this month they announced the presence of important structural differences between the human and plasmodium enzyme. They are now designing new drugs capable of inhibiting the plasmodium enzyme so that compating the spread of drug resistance and they expect to develop a highly specific drugs. In 2006 the researchers began to study the genome of plasmodium and they succeeded in extracting TMP kinase. Later on over one year, Mr Mahmoud Kandeel supervised a work to identify the structural differences between human and plasmodium enzymes. The head of lab Dr Kitade would like to use these structural differences for developing a highly selective antimicrobial drug. A research paper summarizing these results was published in January issue of the british Parasitology journal, the figure prepared by Mr Mahmoud Kandeel to show the structural differences between the human and plasmodium enzyme was used to decorate the cover of this scientific journal. Now the research team are now collaborating with structural biology lab for revealing the X-ray three dimensional structure of the plasmodium enzyme which will help in developing a specific inhibitors. Malaria Is a mosquito-borne infection. the symptoms includes high fever with shivering. There are 4 nain types of malaria but the most severe disease is caused by Plasmodium falciparum. The disease is widely spread in Africa, asia, middle and south America, infecting more tham 300 million people with more than 2 million deaths every year

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